Although the role of acetylcholine as a neurotransmitter is well known, growing evidence points to acetylcholine as a ubiquitous cytokine-like molecule that regulates basic cellular processes such as proliferation, differentiation, locomotion, and secretion in a paracrine and autocrine fashion. Indeed, this modulatory role may contribute to the cutaneous activity of DMAE. These effects did not regress during a 2-week cessation of application.
Application was found to be well tolerated, with no differences in the incidence of erythema, peeling, dryness, itching, burning, or stinging between the DMAE and placebo groups. Apply market research to generate audience insights. Measure content performance. Develop and improve products. List of Partners vendors. DMAE also known as dimethylaminoethanol, dimethylethanolamine, or Deanol is a compound sometimes used as an ingredient in lotions, creams, and other skincare products.
It is also available in dietary supplement form. DMAE is hypothesized to increase the production of acetylcholine a chemical that helps nerve cells transmit signals. Since acetylcholine plays a key role in many brain functions, such as learning and memory, proponents claim that taking DMAE in supplement form may boost brain health by raising acetylcholine levels.
Drugs that raise acetylcholine levels have been used to treat Alzheimer's disease, so some studies have looked at DMAE as a potential Alzheimer's treatment. So far, however, they've failed to show any promising results.
A study on nutritional treatments stated that it "probably has a small effect. In addition, DMAE has been looked at to boost athletic performance, elevate mood, and address symptoms of depression. Currently, the effects of DMAE aren't scientifically well documented.
DMAE cream, lotion, and other skin-care products are said to offer anti-aging benefits by reducing the appearance of wrinkles, dark under-eye circles, and sagging neck skin. For instance, a review published in the American Journal of Clinical Dermatology states that DMAE may help to increase skin firmness and curb inflammation in the skin.
In their analysis of previously published research, the review's authors found that DMAE may help to lessen fine wrinkles on the forehead and around the eyes and improve the overall appearance of aging skin. What's more, the review's authors noted that DMAE did not appear to cause common side effects such as redness, peeling, and dryness.
In a preliminary study published in Pharmazie in , topically applied DMAE led to increased thickness of the epidermal and dermal skin layers in contrast, application of formulations without DMAE increased thickness of the epidermal layer only. For a study published in the Journal of Alzheimer's Disease in , people all of whom were diagnosed with early-stage Alzheimer's disease took either a placebo or an oral DMAE extract known as V every day for 24 weeks.
At the study's end, there was no significant difference in cognitive function between the two groups. The studies noted that there may have been several issues in the study design, including a relatively short treatment period, a lack of valid measures to assess the study participants, and issues with assessing changes in cognitive function over time.
There's also no evidence that oral DMAE supplements can treat depression or improve sports performance. If we talk about its use in dermocosmetic products for skin care, the DMAE is a great ally to fight against visible signs of aging thanks to its tightening and firming action that also provides a great hydration to the skin and improves the spots, unifying the skin tone.
It is highly indicated for those people concerned about the loss of skin elasticity. It is a totally effective asset with visible effects but we must be constant in its application and combine it with other assets that enhance its effect and its immediate action on visible signs. DMAE is an active ingredient that c an be used by all skin types, even the most sensitive.
However, as with the other active ingredients, we must be aware of what type of skin we have and what we need. It can also be found in small amounts in the human body, typically in the brain and adrenal glands. DMAE has become popular as both a consumable supplement and in skin care formulations, and although its actual function on the skin is not fully understood, it has been shown to reduce the appearance of fine lines and pores. We love it for its effectiveness on maturing skin, although those with very sensitive skin may find it produces redness.
As mentioned, DMAE is typically found in fish, however, we use a vegan version. Although ours is technically synthetic because it is made in the lab, it is a nature-identical molecule that has the exact structure of DMAE found in nature. We prefer this source because the chemistry is still green and safe, lab-produced is more sustainable in this instance, and of course, no animals were harmed in its production!
On its own, DMAE is dangerously alkaline and in skin care is commonly mixed with tartaric acid to make it usable. Before use please store in a cool dark area in a well-sealed container.
DMAE is water soluble, so ideally it should be added during the water phase of an emulsion. We use DMAE in a variety of products, including emulsions like lotions and creams, toners, masks, or really anything hydrous. It works well with most ingredients and there are no contraindications that would limit its use.
With a little education, your customers will appreciate having this excellent ingredient as a star player in your line, so we encourage you to try a sample of any of the below! DMAE Gel — use as a moisturizing aloe-based gel on the face, body, or specifically under-eye area.
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