Where is estrogen produced post menopause

Instead, it is produced in a number of extragonadal sites and acts locally at these sites as a paracrine or even intracrine factor. These sites include the mesenchymal cells of adipose tissue including that of the breast, osteoblasts and chondrocytes of bone, the vascular endothelium and aortic smooth muscle cells, and numerous sites in the brain.

Thus, circulating levels of estrogens in postmenopausal women and in men are not the drivers of estrogen action, they are reactive rather than proactive. This is because in these cases circulating estrogen originates in the extragonadal sites where it acts locally, and if it escapes local metabolism then it enters the circulation. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, log in to check access. Greenblatt, R. Ovarian and adrenal steroid production in the postmenopausal woman. Hensell, D. Plasma precursors of estrogens. Correlation of the extent of conversion of plasma androstenedione to estrone with age. Judd, H. Email to Friend.

Email a Friend close. Your friend will receive an e-mail invitation to view this page, but we will not store or share this e-mail address with outside parties. What does this hormone do?

Stimulates growth of breast tissue Maintains vaginal blood flow and lubrication Causes lining of the uterus to thicken during the menstrual cycle Keeps vaginal lining elastic Many other functions, including preserving bone.

Prepares lining of the uterus for a fertilized egg and helps maintain early pregnancy. How do menopause and age affect this hormone? During perimenopause, levels fluctuate and become unpredictable. Eventually, production falls to a very low level.

Google Scholar. Cite Cite J. Select Format Select format. Permissions Icon Permissions. Abstract The purpose of the present study was to investigate the mechanisms by which estrogen production arises in the human female following the menopause.

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